Cardiac Ion Channel Screen Panels

The drug-induced cardiovascular complications restrict the use of many successful clinical treatments such as anticancer therapies. The majority drug-induced cardiovascular complications include overt cardiac dysfunction as well as some negative impact such as hypertension, ischemia, and arrhythmias. Enormous efforts and investments have been made throughout the process of new drugs development to identify adverse effects of cardiovascular systems and minimize the risks for patients. Approximately one third of compounds in pre-clinical development exhibit some levels of cardiac risks.

One of the most important cardiovascular (CVS) liabilities in safety pharmacology is the life-threatening condition known as Torsades de pointes (TdP) which is principally mediated by changes in the activity of the hERG (Kv11.1) channel and other important cardiac ion channels (Cav1.2, Nav1.5, Kv4.3, Kir2.1 and Kv7.1). Many compounds can affect the activities of the ion channels or transporters, thus have the potential of delaying the ventricular repolarization and leading to prolonged QT interval.

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