What is Cell Line Authentication?

Creative Bioarray provides the world’s most comprehensive list of cells, and has realized that animal and human primary cells, tumor cell lines, continuous (immortalized) cell lines, and tissues are very important to the biopharmaceutical industry and to biomedical research as reagents, therapeutic modalities, and as proxy materials. Cell cultures have been at risk for misidentification due to labeling errors, incorrect classification by pathologists, and cross-contamination with other cell types. Continuous cell lines are potentially jeopardized due to the extended time these are in culture and the frequent manipulations involved in the course of feeding and subculturing. Human stem cell preparations which are propagated in the presence of non-human feeder cell layers are at risk of cross-contamination with the feeder cells. Tumor cells propagated by xenografting onto host animals are at risk of cross-contamination with the host cells.

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